   Wiebke Arlt, MD – Ernst Oppenheimer Award. This annual award is presented to young investigators in recognition of accomplishments in the field of basic or clinical endocrinology. Arlt identified the first P450 human oxidoreductase mutations. She first identified the mutation while working with the Endocrine Group at the University of Birmingham. This discovery was followed by her discovery of another monogenic form of hyperandrogenism related to defective DHEA sulphation. Arlt resides in Birmingham, United Kingdom.

   Kathryn Bloch Horwitz, PhD – Fred Conrad Koch Award. This annual award recognizes exceptional contributions to endocrinology and includes a $25,000 honorarium. Horwitz’s contributions include research on the action of steroid receptors in breast cancers, as well as generating the first anti-progesterone receptor monoclonal antibodies which fundamentally altered methods for experimental and clinical receptor measurements. Her research group was also the first to define a third progesterone receptor isoform, PR-C, now thought to trigger onset of labor at parturition. Horwitz resides in Greenwood Village, Colorado.

   Myles Brown, MD – Edwin B. Astwood Award Lecture. This annual award recognizes outstanding research in endocrinology. Brown has made substantive contributions to the understanding of the central role played by co-activators in hormone action. Brown discovered that even in the constant presence of ligand, co-activators cycle on and off the receptors. Recently, Brown observed that steroid receptors bind to thousands of genomic sites far from the start sites of genes. Brown resides in Boston, Massachusetts.

   Hossein Gharib, MD – Distinguished Physician Award. This annual award recognizes outstanding contributions to the practice of clinical endocrinology. Over his 40-year career, Gharib has become an internationally known authority on thyroid disorders. His contributions to clinical practice include confirming the utility of the TSH radioimmunoassay in thyroid practice, developing the first radioimmunoassay to measure T3 in human serum, emphasizing the importance of thyroid nodules in clinical practice and the limitations of cytologic diagnosis. Gharib was also one of the first to draw attention to the prevalence and management of incidentally discovered thyroid nodules. Gharib resides in Rochester, Minnesota.

   Mark O. Goodarzi, MD, PhD – Richard E. Weitzman Memorial Award. This annual award recognizes an exceptionally promising young clinical or basic investigator. Goodarzi is recognized for scientific achievements in the study of genetic epidemiology of common metabolic and hormonal disorders and genetic investigation of insulin-related traits in Hispanic Americans. His work has suggested that polycystic ovary syndrome may in part be determined by inherited heightened androgen sensitivity. Goodarzi resides in Los Angeles, California.

   Barbara B. Kahn, MS, MD – Gerald D. Aurbach Award Lecture. This annual award recognizes outstanding contributions to research in endocrinology. Kahn is recognized for her research in understanding the molecular mechanisms underlying type 2 diabetes and the cellular physiologic processes that render obesity a major risk factor for type 2 diabetes. Kahn’s laboratory also made a seminal discovery that regulation of the AMP-kinase pathway is critical for leptin action on both fatty acid oxidation in muscle and food intake and body weight control via the hypothalamus. Kahn resides in Cambridge, Massachusetts. 

   Sundeep Khosla, MD – Clinical Investigator Award Lecture. This annual award honors an internationally recognized clinical investigator who has contributed significantly to the pathogenesis, pathophysiology and therapy of endocrine diseases. Khosla is recognized for his remarkable research as a clinical investigator of bone and mineral disorders. As a member of the Mayo group, his primary focus has been a comprehensive assessment of all aspects of osteoporosis.  He has been able to demonstrate that estrogen, but not testosterone, was the dominant regulator of bone resorption, whereas both steroids were regulators of bone formation. In other studies, Khosla and his colleagues have defined the natural history of bone loss and age-related fractures in women and men and identified important associated risk factors. Khosla resides in Rochester, Minnesota.

   Martin M. Matzuk, MD, PhD – Roy O. Greep Award Lecture. This annual award recognizes outstanding contributions to research in endocrinology.  Matzuk’s laboratory began using strategies to identify and discover novel gonadal genes with unknown functions and he was able to demonstrate that GDF9 and MBD15 regulate granulose cell function at several stages of ovarian folliculogenesis.  He is recognized as being the first to identify essential mammalian germ cell intercellular bridge protein, TEX 14. Matzuk’s research in male reproduction has led to the discovery of key genes involved in multiple steps of spermatogenesis. Matzuk resides in Houston, Texas.

   Bert W. O’Malley, MD – Robert H. Williams Distinguished Leadership Award. This annual award recognizes outstanding leadership in fundamental or clinical endocrinology. O’Malley has mentored more than 300 students, fellows and faculty and his sustained research leadership has resulted in over 700 peer-reviewed publications and 22 patents. He has served as Chair of Endocrine and ACS Study Sections, popularized the Hormone Action Gordon Conferences, and as president of The Endocrine Society, O’Malley launched the journal Molecular Endocrinology. O’Malley’s laboratory has been a leader in uncovering the mode of action of the female sex steroids progesterone and estrogen. O’Malley resides in Houston, Texas.

    Janet Schlechte, MS, MD – Distinguished Educator Award. This annual award recognizes exceptional achievement as an educator in the discipline of endocrinology and metabolism. As director of postgraduate programs, Schlechte has supervised the training of over 400 medicine residents, chaired the Advisory Committee which oversees house staff education at the University of Iowa, and developed a board review course for residents in internal medicine. She has also supervised research programs for 10 endocrine fellows and/or junior faculty. Schlechte’s contributions to the Society include serving as clinical chair for the Annual Meeting, initiating the Meet the Professor sessions and developing and presenting new educational programs for endocrinologists participating in maintenance of certification. Schlechte resides in Iowa City, Iowa.